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<p><i>In vitro</i> antiproliferative activity of some fused heterocyclic compounds containing a pyrrolo[3,4-<i>d</i>]isoxazole framework was studied against human cervical carcinoma (HeLa), murine fibroblast (3T3) and SV-40 transformed murine fibroblast (3T3-SV40) cell lines. The most active among the studied compounds showed antiproliferative activity at a micromolar concentration range (up to 16 μM) that resulted in actin filament disappearance and granular actin diffuse distribution in the cytoplasm of up to 71% of HeLa cells.</p>

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In Vitro Activity of Pyrrolo[3, 4-D]Isoxazoles Against Hela, 3T3 and 3T3-SV40 Cell Lines

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • E. A. Makhneva,
  • Z. P. Sosnovitskaya,
  • S. V. Shmakov,
  • M. S. Ledovskaya,
  • A. V. Stepakov,
  • V. M. Boitsov

摘要

In vitro antiproliferative activity of some fused heterocyclic compounds containing a pyrrolo[3,4-d]isoxazole framework was studied against human cervical carcinoma (HeLa), murine fibroblast (3T3) and SV-40 transformed murine fibroblast (3T3-SV40) cell lines. The most active among the studied compounds showed antiproliferative activity at a micromolar concentration range (up to 16 μM) that resulted in actin filament disappearance and granular actin diffuse distribution in the cytoplasm of up to 71% of HeLa cells.