Application of Technological and Physical-Chemical Approaches to the Development of Injection Forms of an Indolocarbazole Derivative
摘要
The development of a rational dosage form for an API is one of the main links in the chain of comprehensive research to create a drug. The purpose of this study was to use physicochemical and technological methods to create various parenteral forms based on the practically water-insoluble API LCS-1269 and to conduct a comparative study of the developed dosage forms according to the main quality indicators characteristic of injectable dosage forms. Compositions and technologies for producing three model dosage forms based on LCS-1269 were evaluated during the work. Their main advantages and disadvantages were shown.