Improvement Biological Activity of Tetracycline Drug

The development of innovative antibiotic medications is particularly crucial since the increased bacterial resistance to antibiotics poses a serious danger to human health. Here, an adamantine moiety-containing family of Schiff base tetracycline derivatives was created and the structural characterization of the compounds was carried out via spectral methods (FTIR and ¹H NMR), after which the physical properties of the synthesis compounds and the biological activity were tested in vitro. The Schiff bases derived from tetracycline show significantly higher activity against Gram-positive bacteria as compared to tetracycline. Further study on these derived compounds will help in marketing new derivatives of tetracycline that will have more broad-spectrum activity than tetracycline.