Synthesis and Analgesic Activity of 2-(3,3-Dimethyl-3,4-Dihydroisoquinolin-1-yl)-2-(2-Arylhydrazono)-N-(2,4-Xylyl)-Acetamides
摘要
Azo coupling reactions of (Z)-2-(3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)ylidene)-N-(2,4-xylyl)-acetamide with diazonium salts were used to synthesize 2-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-2-(2-arylhydrazono)-N-(2,4-xylyl)-acetamides. All compounds showed analgesic effects in the hotplate test, exceeding the effect of metamizole sodium. In the case of the most active hydrazone, the defensive reflex time in mice was 27.10 min (compared with 16.60 min for metamizole sodium).