Ways of Preparing and Using Biologically Active and Medicinal Compounds Labeled with Hydrogen Isotopes (Review)
摘要
Various ways of using biologically active compounds labeled with hydrogen isotopes are described. The use of labeled compounds in studies of ligand(receptor binding, pharmacokinetics, the effects of biologically active compounds on the functioning of the body at the cellular level, etc., is demonstrated. The main methods of introducing hydrogen isotopes into compounds that are considered candidates and medicines are given. Attention is paid to methods of isolating labeled compounds and determining their characteristics (yield, label distribution, amount of included isotope).