Behavioral and Receptor Effects of N-Arachidonoyl-Gaba Under Conditions of Permanent Bilateral Carotid Arteries Stenosis in Rats

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发表日期：

2024年9月1日

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E. V. Vasileva,
A. A. Abdullina,
E. A. Kondrakhin,
A. V. Gnezdilova,
T. S. Gan’shina,
R. S. Mirzoyan,
N. M. Gretskaya,
V. V. Bezuglov,
G. I. Kovalev

摘要

The effects of the endogenous neuroprotector N-arachidonoyl-GABA on the cognitive functions and NMDA- and GABA_A-receptor characteristics in the brain of rats under bilateral common carotid artery stenosis were studied. Administration of the compound (2 mg/kg, 7 d) to ischemic rats normalized cognitive performance in the exploratory plus-maze test and decreased the ex vivo number of cortical GABA_A receptors by 17%, partially returning it to the normal values. N-Arachidonoyl-GABA did not correct the density of NMDA receptors that was altered by ischemia. Thus, N-arachidonoyl-GABA was able to restore receptor levels and cognitive activity disturbed by stenosis.