Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids

The pharmacological activity of flavonoids as potential candidates for the development of drugs based on biologically active substances of plant origin is confirmed by research data. The low bioavailability of flavonoids attributed to poor solubility and absorption in the gastrointestinal tract is a limiting factor in their use. Microand nano-milling technologies; complexation with surfactants, cyclodextrins, and chelating agents; and production of solid disperse systems are currently used to improve the physicochemical properties of polyphenolic compounds. Development of solid dispersion systems using hot melt extrusion is the most promising approach from the viewpoint of industrial implementation. The present review is devoted to consideration of current approaches to the use of hot extrusion of polyphenolic compounds to improve their pharmacokinetic and technological properties.