Toxicity and Antihypoxic Activity of a Preparation Containing a Complex Compound of 5-Hydroxy-6-Methyluracil with N-Acetyl Cysteine
摘要
5-Hydroxy-6-methyluracil (5-OH-6-MU) was shown to form a 1:1 complex with N-acetylcysteine (N-AC), i.e., the compounds interacted in an equimolar ratio. The temperature dependence of the stability constant was studied in the range 291-316 K. The thermodynamic parameters of the complexation process were determined. Aprocedure for the synthesis of the 5-OH-6-MU…N-AC complex was developed based on the results. The toxicity and antihypoxic activity of the complex were subsequently studied. The synthesized compound at a dose of 500 mg/kg in mice had low toxicity and antihypoxic activity significantly superior to those of the reference drugs (5-OH-6-MU and N-AC).