Design, Synthesis and Biological Evaluation of Amide Derivatives of Thiazole-Indole-Isoxazoles as Anticancer Agents

A new library of amide derivatives of thiazole-indole-isoxazoles 11a-j has been prepared and their structures were confirmed by analytical data. Further, all the compounds were preliminarily assessed for their cytotoxic activities against human cancer cell lines such as breast cancer (MCF-7), lung cancer (A549) and prostate cancer (PC3&DU-145) by using MTT assay. The results were compared with the well-recognized drug candidate, etoposide. Most of the tested compounds showed moderate cytotoxic activity. Among them, five compounds, 11a, 11b, 11c, 11g, and 11i displayed significant potential activity.