Synthesis and Antiulcer Activity of Aromatic and Heterocyclic Amides of 3-O-Acetylglycyrrhetic Acid
摘要
C30-amides of 3-O-acetylglycyrrhetic acid containing aromatic and heterocyclic pharmacophores were synthesized by the acid chloride method. The antiulcer activity of 3-O-acetylglycyrrhetic acid amides with piperazine (IV), aniline (VI), and 2-aminothiazole-3-phenyl (X) was studied in the indomethacin ulcer model of the gastric mucosa of rats at a dose of 50 mg/kg. Amides IV and X had the highest antiulcer activity comparable to that of the reference drug Omez.