<p>Psychedelic-assisted therapy (PAT) is emerging as a promising treatment in the field of clinical mental health. Many who have participated in PAT or used psychedelics in other contexts have reported experiences of profound healing, whether mental, emotional, spiritual, or a combination thereof. Research suggests there may be a correlation between mental health outcomes and how spiritual the experience is understood to be. Spiritually significant psychedelic experiences, whether during PAT or psychedelic use in other contexts, are reported as incredibly healing and transformative. Similar to the therapeutically healing and spiritually transformative power of spiritually significant psychedelic experiences, contemplative practices can be both healing and transformative for individuals. Contemplative practices have been used for centuries to promote spiritual healing and transformation, often accompanied by enhanced mental and emotional health. One such practice is centering prayer (CP), developed by Thomas Keating and colleagues in the second half of the 20th century. The CP method seeks to integrate knowledge from modern psychology with the wisdom found in ancient contemplative practices and teachings. This paper’s first section reviews the history of psychedelic research, specifically that relating to religion/spirituality, and presents a common framework for understanding the unconscious in PAT. The second section introduces the practice of CP and presents its framework for understanding the unconscious. The third section reviews research on psychedelics and meditation and empirical studies on CP. This is followed by a discussion of the possible benefits of connecting PAT and CP, a discussion of possible adverse effects, and suggestions for future research. As a whole, the paper considers whether or not intentional psychedelic use and the contemplative practice of CP may be two methods that can work together to promote healing, transformation, and wholeness.</p>