<p>In prior research, religiosity has long been associated with psychological well-being. Yet, the mechanisms underlying this relationship remain insufficiently explored among women in consecrated life, especially in non-Western settings. This study examined whether meaning in life mediates the relationship between religiosity and psychological well-being among Catholic sisters in Indonesia. A total of 277 participants completed the Centrality of Religiosity Scale (CRS), the Meaning in Life Questionnaire (MLQ), and Ryff’s Psychological Well-Being Scale (PWB). Data were analyzed using Pearson’s correlations, linear regression, and classic mediation criteria analysis following Baron and Kenny’s (1986) approach, verified by the Sobel test. Results indicated that religiosity was positively correlated with both meaning in life and psychological well-being and that meaning in life fully mediated the association between them. The indirect effect was significant (<i>Z</i> = 3.12, <i>p</i> = .002), suggesting that religiosity contributes to well-being primarily through the enhancement of existential meaning among women religious in Indonesia. These findings provide cross-cultural support for a eudaimonic model of well-being and underscore the central role of meaning as a psychological mechanism linking faith and flourishing. Implications are discussed for pastoral formation and meaning-centered interventions designed to strengthen resilience and vocational maturity among women religious.</p>