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<p>Nanoparticles (NPs) of porous silicon (PSi) were loaded by Methylene blue (MB). The MB photoluminescence in the spectral region of 650–800&#xa0;nm when excited by He-Ne laser at a wavelength of 633&#xa0;nm. The polarization memory method was considered to make a decision about the state of MB (inside NPs or free MB in aqueous solution). The values of polarization for free MB and loaded MB were 6.2 and 9.5%, respectively. The MB release from the nanocontainer based on PSi NPs was found to be significantly promoted by nanosecond laser irradiation at 532&#xa0;nm because of the local laser-induced heating of PSi NPs. The local heating was assessed by the Raman scattering method. The temperature of NPs increase was 30–50 degrees. This result allows us to control the release of MB from nanocontainers, which expands the possibilities of its use in combination cancer therapy.</p>

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Laser-induced release of methylene blue from porous silicon nanoparticles for combined cancer therapy

  • 期刊论文

  • 发表日期：

    2026年1月24日

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  • А. А. Bubnov,
  • N. S. Pokryshkin,
  • V. Yu. Timoshenko

摘要

Nanoparticles (NPs) of porous silicon (PSi) were loaded by Methylene blue (MB). The MB photoluminescence in the spectral region of 650–800 nm when excited by He-Ne laser at a wavelength of 633 nm. The polarization memory method was considered to make a decision about the state of MB (inside NPs or free MB in aqueous solution). The values of polarization for free MB and loaded MB were 6.2 and 9.5%, respectively. The MB release from the nanocontainer based on PSi NPs was found to be significantly promoted by nanosecond laser irradiation at 532 nm because of the local laser-induced heating of PSi NPs. The local heating was assessed by the Raman scattering method. The temperature of NPs increase was 30–50 degrees. This result allows us to control the release of MB from nanocontainers, which expands the possibilities of its use in combination cancer therapy.