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<p>In this study, the detection capability of biological threat agents was investigated using a multispectral nanoplasmonic aptasensor based on a Di-supercell metamaterial. This configuration consists of two supercells: one circular and the other square, with a square cell placed inside a circular cell, creating the proposed structure. The three-dimensional finite difference time domain (FDTD) simulation method also confirmed the validity of the findings. The detection of biomolecules in traditional biosensors, especially in the presence of low analyte concentrations, is challenging and requires the use of sensors with superior sensitivity (S). Based on the results obtained, the designed structure exhibits sensitivities of 539.43 and 644.29&#xa0;nm/RIU in modes I and II. The presence of two resonance modes in this structure makes it an ideal choice for multispectral applications. Our findings suggest that this has structure substantial promise for a variety of biological applications. In this study, both silver and gold metals were evaluated as plasmonic materials. Our novel design features a unique arrangement that allows for maximum interaction of cells with the target analyte. This optimized structure provides a suitable platform for enhancing the sensitivity and accuracy of analyte detection and, given the level of sensitivity, is an appropriate option for the identification of biological threat agents.</p>

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Multispectral plasmonic aptasensor based on a di-supercell metamaterial for detection of biological threat agents

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • Reza Sepahvand,
  • Seyed Roohollah Mirakbari

摘要

In this study, the detection capability of biological threat agents was investigated using a multispectral nanoplasmonic aptasensor based on a Di-supercell metamaterial. This configuration consists of two supercells: one circular and the other square, with a square cell placed inside a circular cell, creating the proposed structure. The three-dimensional finite difference time domain (FDTD) simulation method also confirmed the validity of the findings. The detection of biomolecules in traditional biosensors, especially in the presence of low analyte concentrations, is challenging and requires the use of sensors with superior sensitivity (S). Based on the results obtained, the designed structure exhibits sensitivities of 539.43 and 644.29 nm/RIU in modes I and II. The presence of two resonance modes in this structure makes it an ideal choice for multispectral applications. Our findings suggest that this has structure substantial promise for a variety of biological applications. In this study, both silver and gold metals were evaluated as plasmonic materials. Our novel design features a unique arrangement that allows for maximum interaction of cells with the target analyte. This optimized structure provides a suitable platform for enhancing the sensitivity and accuracy of analyte detection and, given the level of sensitivity, is an appropriate option for the identification of biological threat agents.