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<p>We investigate the enhancement of the electromagnetic field and the surface-enhanced Raman scattering (SERS) effect in a silver-plastic metasurface. Localized plasmon modes are excited and manifest as pronounced local maxima of the electric field, spatially confined within the dented regions of the metasurface where the silver layer exhibits minimal thickness. The spectral position of these plasmonic resonances is highly sensitive to both the silver film thickness and the non-uniformity of its distribution across the metasurface. Experimental results show good agreement with numerical simulations performed for a double-periodic metal-dielectric metasurface. The fabricated metasurface was evaluated as a SERS substrate for direct detection of individual extracellular vesicles from the Human Embryonic Kidney 293T cell line.</p>

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Flexible metasurfaces for direct SERS identification of single extracellular vesicles

  • 期刊论文

  • 发表日期：

    2025年9月29日

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  • Andrey Ivanov,
  • Konstantin Mochalov,
  • Denis Korzhov,
  • Milena Shestopalova,
  • Igor Bykov,
  • Konstantin Afanasev,
  • Alexander Smyk,
  • Alexander Shurygin,
  • Andrey K. Sarychev

摘要

We investigate the enhancement of the electromagnetic field and the surface-enhanced Raman scattering (SERS) effect in a silver-plastic metasurface. Localized plasmon modes are excited and manifest as pronounced local maxima of the electric field, spatially confined within the dented regions of the metasurface where the silver layer exhibits minimal thickness. The spectral position of these plasmonic resonances is highly sensitive to both the silver film thickness and the non-uniformity of its distribution across the metasurface. Experimental results show good agreement with numerical simulations performed for a double-periodic metal-dielectric metasurface. The fabricated metasurface was evaluated as a SERS substrate for direct detection of individual extracellular vesicles from the Human Embryonic Kidney 293T cell line.