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<p>In this study, we present a novel drug-functionalized Graphene quantum dots (GQDs) as an effective system for drug delivery as well as imaging. The aforementioned GQDs are chosen in two different sizes in order to examine the effect of quantum confinement on our systems. As an effective drug for cancer treatment, Doxorubicine (DOX) is the studied element due to its organic nature. The optoelectronic and photoluminescence responses of different configurations of DOX bonding with GQDs are computationally investigated to assess their effectiveness in nanomedical fields to aimed target. The absence of negative frequencies reveals the stability of the new combined structures. Furthermore, H-L energy gap decreases with the increment of QDs size and mainly depends on Dox bonding on GQDs as well its the hardness of the nanoparticles. Consequently, the optical absorption and emission spectra undergo a red-shift after DOX coupling. In addition, GQDs+drug exhibit a strong photoluminescence in the Near-infrared region. This optical profile prompts the suitability of the coupled systems for drug delivery and nanomedical diagnostic applications.</p>

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Design of new DOX coupling GQDs nanoparticles with enhanced optoelectronic features for drug delivery

  • 期刊论文

  • 发表日期：

    2025年1月11日

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  • Kenza Elkabiri,
  • Hala Ouarrad,
  • Lalla Btissam Drissi

摘要

In this study, we present a novel drug-functionalized Graphene quantum dots (GQDs) as an effective system for drug delivery as well as imaging. The aforementioned GQDs are chosen in two different sizes in order to examine the effect of quantum confinement on our systems. As an effective drug for cancer treatment, Doxorubicine (DOX) is the studied element due to its organic nature. The optoelectronic and photoluminescence responses of different configurations of DOX bonding with GQDs are computationally investigated to assess their effectiveness in nanomedical fields to aimed target. The absence of negative frequencies reveals the stability of the new combined structures. Furthermore, H-L energy gap decreases with the increment of QDs size and mainly depends on Dox bonding on GQDs as well its the hardness of the nanoparticles. Consequently, the optical absorption and emission spectra undergo a red-shift after DOX coupling. In addition, GQDs+drug exhibit a strong photoluminescence in the Near-infrared region. This optical profile prompts the suitability of the coupled systems for drug delivery and nanomedical diagnostic applications.