<p>To extend the service life of aircraft hydraulic pipes, this study proposes a quasi-zero stiffness constraint (QZS-C) to suppress resonance-induced fatigue fractures. A nonlinear dynamic model of the fluid-conveying pipe with QZS-C is established, integrated with a fatigue life prediction based on Paris’ law. The Galerkin truncation method combined with the harmonic balance method is adopted to characterize the pipe’s nonlinear dynamic response. The vibration response, stress, and fatigue life of the pipe with different constraint are systematically investigated. Results show that the pipe with double-layer QZS-C achieves superior vibration suppression via a pronounced phase lag induced by its damping characteristics. Compared with conventional retaining clip and rigid constraints, the QZS-C effectively mitigates resonance, reduces dynamic stress amplitude, and significantly extends fatigue life of pipes. Furthermore, the dynamic evolution of pipe fatigue with QZS-C location is clarified. And the minimum fatigue life of pipes under different QZS-C locations is determined. This work provides an innovative solution for vibration suppression and fatigue life extension of fluid-conveying pipes in high-dynamic service environments.</p>