<p>In this paper, we study the existence of bifurcation of a van der Pol-Duffing oscillator with quintic terms and its quasi-periodic solutions by means of qualitative and bifurcation theories. Firstly, we analyze the autonomous system and find that it has two kinds of local bifurcations and a global bifurcation: pitchfork bifurcation, Hopf bifurcation, homoclinic bifurcation. It is worth noting that the disappearance of the homoclinic orbit is synchronized with the emergence of a large limit cycle. Then, by discussing the stability of equilibria at infinity and the orientation of the trajectory, the existence and stability of limit cycles of the autonomous system are analyzed by combining the Poincaré-Bendixson theorem and the index theory. The global phase portrait and the numerical simulation of the autonomous system in different parameter values are given. Finally, the existence of quasi-periodic solutions to periodic forced system is proved by the KAM method.</p>