<p>Peru is located within the seismically active “Pacific Ring of Fire” and therefore is constantly affected by the dynamic interaction of the Nazca and South American Plates. Due to its location, over the past centuries, devastating earthquakes have hit the country, generating substantial economic and human losses, leading to a constant need to overcome and enhance human safety and building integrity through advanced strategies to mitigate seismic risk. This practice has worldwide been cataloged as “Disaster Risk Reduction Management”, which involves a deeper comprehension and representation of the seismic hazard for the assessment of the existing buildings and infrastructure, which often deviates from the practices behind seismic design standards. In this study, a novel approach is proposed to assess seismic hazards at a city-size level. It employs uniform hazard spectra calculated through a comprehensive probabilistic hazard assessment framework. The methodology considered a vast earthquake catalog comprising 22,399 events, 33 earthquake source models derived from previous research, six ground motion prediction models, and five return periods, applied to 25 cities. To address the uncertainties associated with the correctness and accuracy of the results, they were evaluated using a rigorous selection criterion through a logic tree-based weighting system. This accounts for soil classification and fault activity clustered by inter-slab, crustal and intra-slab earthquakes. The findings revealed the specific fault segments influencing the seismic activity for every analyzed city, and also determined if they were in proximity or within the same seismic hazard zone stated within the design standard. This approach can be extended looking forward towards establishing a more reliable seismic hazard comprehension based on local activity, offering valuable insights for the performance-based assessments of existing structures and for the formulation of preparedness policies.</p>