<p>This study examines impact of industry network (IN) structure on economic performance through intensifying production factors, using the OECD input–output tables for China, Japan, the U.S. and Russia on an extended Cobb-Douglas production function. IN is modeled on Weaver-Thomas Index and IN structure is measured by density, centrality and cohesion. We proposed IN structure can produce integrated effects on economic output by intensifying production factors, and an extended Cobb-Douglas production function is developed. We found structure feature and its impact on economic performance are heterogeneous. We conducted an analysis using a single-breakpoint piecewise regression model. The low out-degree centrality (<i>od</i>) and in-degree centrality (<i>id</i>) as labor-weakening and labor-enhancing moderators respectively and a low output-elasticity of labor indicate semi-star China economy in the second time period; the high <i>id</i> as the labor-weakening moderator and a high income elasticity of labor indicate inverse-star Russia economy in the second time period; the moderate centrality as the labor-enhancing moderator, and a high income elasticity of labor for Japan and the U.S. indicate star economies in the first time period.</p>