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<p>The interaction between immune system dysfunction and neuroinflammation is crucial for the development and progression of epilepsy. This study investigates the complex relationships between immune responses and the onset of epileptic seizures and highlights the influence of neuroinflammatory processes on neuronal integrity and seizure frequency. Key factors such as glial cell activation, release of pro-inflammatory cytokines, and disruption of the blood-brain barrier (BBB) are being investigated for their roles in immune-mediated neurological disorders. The review examines novel therapeutic approaches targeting neuroinflammatory pathways. It highlights their potential to reduce seizure onset and development while addressing challenges in translating research into clinical practice. This study aims to elucidate these pathways, address knowledge gaps and explore novel options for epilepsy treatment.</p>

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“Targeting Neuroimmune Pathways in Epilepsy: Advances in Mechanisms and Emerging Therapeutics”

  • 期刊论文

  • 发表日期：

    2025年7月22日

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  • Manish Ravikumar,
  • Deenathayalan Uvarajan,
  • Brindha Durairaj

摘要

The interaction between immune system dysfunction and neuroinflammation is crucial for the development and progression of epilepsy. This study investigates the complex relationships between immune responses and the onset of epileptic seizures and highlights the influence of neuroinflammatory processes on neuronal integrity and seizure frequency. Key factors such as glial cell activation, release of pro-inflammatory cytokines, and disruption of the blood-brain barrier (BBB) are being investigated for their roles in immune-mediated neurological disorders. The review examines novel therapeutic approaches targeting neuroinflammatory pathways. It highlights their potential to reduce seizure onset and development while addressing challenges in translating research into clinical practice. This study aims to elucidate these pathways, address knowledge gaps and explore novel options for epilepsy treatment.