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<p>Chronic constriction injury (CCI) is a&#xa0;well-established experimental model used to study neuropathic pain, and herbal plants and their derivatives play a&#xa0;critical role in modern drug development. One such plant, Potentilla reptans L.&#xa0;root (PR), is known for its antioxidant and anti-inflammatory properties, represents a&#xa0;promising natural product for alleviating neuropathic pain. This study investigates the neuroprotective effects of PR extract on neuropathic pain induced by CCI in rats. In this study, Nociceptive behavior was quantitatively evaluated using cold allodynia and thermal hyperalgesia assays, histopathological changes in the dorsal horn of the spinal cord were examined using H&amp;E staining, and oxidative stress factors (MDA, SOD, GPX, TAC), inflammation markers (IL1‑B, TNF-α), and liver enzymes (ALT, AST) were measured. The results demonstrated that PR treatment significantly alleviated pain hypersensitivity, reduced oxidative stress and inflammatory markers and decreased neuronal damage, indicating that PR exhibits neuroprotective properties by attenuating CCI-induced injury.</p> Graphic abstract <p></p>

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Neuroprotective effects of potentilla reptans L. root extract in a rat model of chronic constriction injury-induced neuropathic pain

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Mohammad Reza Naghdi Badi,
  • Negin Khosravipour,
  • Setareh Dehkhodaei,
  • Ayesheh Enayati,
  • Hamzeh Badeli Sarkala

摘要

Chronic constriction injury (CCI) is a well-established experimental model used to study neuropathic pain, and herbal plants and their derivatives play a critical role in modern drug development. One such plant, Potentilla reptans L. root (PR), is known for its antioxidant and anti-inflammatory properties, represents a promising natural product for alleviating neuropathic pain. This study investigates the neuroprotective effects of PR extract on neuropathic pain induced by CCI in rats. In this study, Nociceptive behavior was quantitatively evaluated using cold allodynia and thermal hyperalgesia assays, histopathological changes in the dorsal horn of the spinal cord were examined using H&E staining, and oxidative stress factors (MDA, SOD, GPX, TAC), inflammation markers (IL1‑B, TNF-α), and liver enzymes (ALT, AST) were measured. The results demonstrated that PR treatment significantly alleviated pain hypersensitivity, reduced oxidative stress and inflammatory markers and decreased neuronal damage, indicating that PR exhibits neuroprotective properties by attenuating CCI-induced injury.

Graphic abstract