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<p>The cricket terminal abdominal ganglion (TAG) serves as an experimental model analogous to the mammalian spinal cord for studying sensorimotor integration. However, further insights into the resting-state (RS) discharge of interneurons and projecting neurons are required to establish a&#xa0;functional model to test lesion-induced changes and potential therapies. In this study, adult male crickets were used for <i>in situ</i> TAG extracellular recordings under intact and RS conditions. Individual spikes were sorted for interspike interval (ISI), burst, autocorrelation, auto-spectral, and fractal analyses. Data from 131 interneurons indicated stable discharge patterns: 79.4% of ISIs were below 80 ms, and 88.6% had coefficients of variation greater than 100%. Burst discharges occurred in 87.8% of the neurons. Sequential ISI patterns (Poincaré plots) displayed a&#xa0;triangular shape with a&#xa0;vertex in quadrant&#xa0;IV in 89% of cases, yielding a&#xa0;median fractal dimension of 1.104. Significant single or multiple spectral peaks were detected in 83.2% of the interneurons, mainly within the &lt; 10 Hz band. These findings suggest that TAG neurons can simultaneously process different information through rhythmic multispectral discharges and through other discharge parameters. The overall characterization provides a&#xa0;framework for the discharge repertoire of TAG interneurons, establishing an experimental model for testing changes induced by lesions, pharmacological or toxic agents, or other interventions with entomological and translational relevance.</p>

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Resting-state discharge patterns of interneurons and projecting neurons in the cricket terminal abdominal ganglia as a multicode sensing experimental model

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Antonio Eblen-Zajjur,
  • Arturo González Olguín,
  • Jorge Mauro Navarro,
  • Sofía Romero,
  • Sofía Encina,
  • Matías Martínez

摘要

The cricket terminal abdominal ganglion (TAG) serves as an experimental model analogous to the mammalian spinal cord for studying sensorimotor integration. However, further insights into the resting-state (RS) discharge of interneurons and projecting neurons are required to establish a functional model to test lesion-induced changes and potential therapies. In this study, adult male crickets were used for in situ TAG extracellular recordings under intact and RS conditions. Individual spikes were sorted for interspike interval (ISI), burst, autocorrelation, auto-spectral, and fractal analyses. Data from 131 interneurons indicated stable discharge patterns: 79.4% of ISIs were below 80 ms, and 88.6% had coefficients of variation greater than 100%. Burst discharges occurred in 87.8% of the neurons. Sequential ISI patterns (Poincaré plots) displayed a triangular shape with a vertex in quadrant IV in 89% of cases, yielding a median fractal dimension of 1.104. Significant single or multiple spectral peaks were detected in 83.2% of the interneurons, mainly within the < 10 Hz band. These findings suggest that TAG neurons can simultaneously process different information through rhythmic multispectral discharges and through other discharge parameters. The overall characterization provides a framework for the discharge repertoire of TAG interneurons, establishing an experimental model for testing changes induced by lesions, pharmacological or toxic agents, or other interventions with entomological and translational relevance.