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<p><b>Aim:</b> This experimental model assesses the neuroleptic and anti-cognitive potential of a&#xa0;hydroethanolic leaf extract of <i>Colocasia esculenta</i> (HECE) using an in vivo model.</p><p><b>Methodology:</b> The study was conducted on Swiss albino mice and comprised two components: cognitive impairment and neuroleptic activity. In the cognitive model, animals were divided into control, negative control, standard, and two treatment groups receiving a&#xa0;hydroethanolic leaf extract of <i>Colocasia esculenta</i> (200 and 400 mg/kg). For neuroleptic assessment, animals were grouped into control (vehicle 10 ml/kg), standard (trihexyphenidyl 10 mg/kg + haloperidol 1 mg/kg), and two test groups receiving the extract (200 and 400 mg/kg) along with haloperidol (1 mg/kg). Behavioural evaluations were performed using the Hebb–William maze, Cook’s pole-climbing test, and haloperidol-induced catalepsy model. Biochemical and histopathological analyses were also conducted.</p><p><b>Results:</b> HECE significantly ameliorate cognitive efficacy in the Hebb–William’s maze (p &lt; 0.01), Cook’s pole-climbing test (p &lt; 0.001), and reversing scopolamine-induced model. In both acute and chronic studies (p &lt; 0.001), HECE produced a&#xa0;dose-proportional decline in haloperidol-induced catalepsy. Histopathological findings confirmed reduced neuronal degeneration, with the 400 mg/kg dose exhibiting neuroprotective efficacy comparable to that of standard drugs. All compounds were neurotoxicity-inactive (0.56–0.89), showed minimal GABA receptor interaction, and limited BBB permeability except for quercetin and dimedone; vitexin, luteolin-7-rutinoside, and orientin exhibited moderate clinical toxicity (0.51–0.52), while AChE activity was restricted to luteolin-7-rutinoside and orientin.</p><p><b>Conclusion:</b> Hydro-ethanolic leaf extract of <i>Colocasia esculenta</i> (HECE) exhibits neurodegenerative activity and might be useful as a&#xa0;therapy for cognitive dysfunction disease. Furthermore, mechanism of action modulations is described for clinical applicability.</p> Graphic abstract <p></p>

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Integrated in vivo evaluation of the neuroprotective potential of Colocasia esculenta leaf extract in scopolamine-induced cognitive impairment and haloperidol-induced catalepsy

  • 期刊论文

  • 发表日期：

    2026年5月21日

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  • Apoorva Mishra,
  • Saumya Das,
  • Manas Kumar Das,
  • Sandip Chatterjee

摘要

Aim: This experimental model assesses the neuroleptic and anti-cognitive potential of a hydroethanolic leaf extract of Colocasia esculenta (HECE) using an in vivo model.

Methodology: The study was conducted on Swiss albino mice and comprised two components: cognitive impairment and neuroleptic activity. In the cognitive model, animals were divided into control, negative control, standard, and two treatment groups receiving a hydroethanolic leaf extract of Colocasia esculenta (200 and 400 mg/kg). For neuroleptic assessment, animals were grouped into control (vehicle 10 ml/kg), standard (trihexyphenidyl 10 mg/kg + haloperidol 1 mg/kg), and two test groups receiving the extract (200 and 400 mg/kg) along with haloperidol (1 mg/kg). Behavioural evaluations were performed using the Hebb–William maze, Cook’s pole-climbing test, and haloperidol-induced catalepsy model. Biochemical and histopathological analyses were also conducted.

Results: HECE significantly ameliorate cognitive efficacy in the Hebb–William’s maze (p < 0.01), Cook’s pole-climbing test (p < 0.001), and reversing scopolamine-induced model. In both acute and chronic studies (p < 0.001), HECE produced a dose-proportional decline in haloperidol-induced catalepsy. Histopathological findings confirmed reduced neuronal degeneration, with the 400 mg/kg dose exhibiting neuroprotective efficacy comparable to that of standard drugs. All compounds were neurotoxicity-inactive (0.56–0.89), showed minimal GABA receptor interaction, and limited BBB permeability except for quercetin and dimedone; vitexin, luteolin-7-rutinoside, and orientin exhibited moderate clinical toxicity (0.51–0.52), while AChE activity was restricted to luteolin-7-rutinoside and orientin.

Conclusion: Hydro-ethanolic leaf extract of Colocasia esculenta (HECE) exhibits neurodegenerative activity and might be useful as a therapy for cognitive dysfunction disease. Furthermore, mechanism of action modulations is described for clinical applicability.

Graphic abstract