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<p>Alzheimer’s disease is a&#xa0;progressive neurodegenerative disorder in which oxidative stress plays a&#xa0;critical role in the onset and progression of pathology. <i>Eclipta alba</i>&#xa0;(L.) Hassk. is a&#xa0;traditional Ayurvedic medicinal plant recognized for its antioxidant activity and neuroprotective effects. The present study evaluated the neuroprotective potential of the crude form of <i>Eclipta alba</i> and a&#xa0;herbomineral formulation of <i>Eclipta alba</i> in amyloid-beta (25–35)-induced rat models of Alzheimer’s disease. The disease pathology was induced by bilateral intrahippocampal infusion of oligomeric amyloid-beta (25–35), followed by 28&#xa0;days of oral treatment with the crude form of <i>Eclipta alba</i> (300 mg/kg) and the herbomineral formulation of <i>Eclipta alba</i> (150 mg/kg). Behavioural assessments using the Open Field Test and Morris Water Maze test revealed that treatment with the herbomineral formulation of <i>Eclipta alba</i> significantly enhanced parameter-specific locomotor activity and improved spatial learning and memory, respectively. Biochemical evaluation demonstrated that treatments with both the crude form of <i>Eclipta alba</i> and the herbomineral formulation of <i>Eclipta alba</i> partially restored reduced glutathione levels and significantly reduced thiobarbituric acid reactive substances levels, suggesting improved antioxidant status and reduced lipid peroxidation. These findings show that <i>Eclipta alba</i> mitigates Alzheimer’s disease-associated cognitive deficits, likely through its antioxidative activity. Although this is a&#xa0;preliminary study, further studies are required to fully establish the neuroprotective potential of <i>Eclipta alba</i> and its suitability for clinical applications.</p>

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Amelioration of amyloid-beta (25–35)-induced neurotoxicity by Eclipta alba (L.) Hassk.: evidence from behavioural and oxidative analyses

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • Abir Biswas,
  • Meher Nisha Abubakkar,
  • Anitha Rathinam,
  • Kumar Surya,
  • Giri Prashanth,
  • Kesavan Swaminathan Jayachandran,
  • Muthuswamy Anusuyadevi

摘要

Alzheimer’s disease is a progressive neurodegenerative disorder in which oxidative stress plays a critical role in the onset and progression of pathology. Eclipta alba (L.) Hassk. is a traditional Ayurvedic medicinal plant recognized for its antioxidant activity and neuroprotective effects. The present study evaluated the neuroprotective potential of the crude form of Eclipta alba and a herbomineral formulation of Eclipta alba in amyloid-beta (25–35)-induced rat models of Alzheimer’s disease. The disease pathology was induced by bilateral intrahippocampal infusion of oligomeric amyloid-beta (25–35), followed by 28 days of oral treatment with the crude form of Eclipta alba (300 mg/kg) and the herbomineral formulation of Eclipta alba (150 mg/kg). Behavioural assessments using the Open Field Test and Morris Water Maze test revealed that treatment with the herbomineral formulation of Eclipta alba significantly enhanced parameter-specific locomotor activity and improved spatial learning and memory, respectively. Biochemical evaluation demonstrated that treatments with both the crude form of Eclipta alba and the herbomineral formulation of Eclipta alba partially restored reduced glutathione levels and significantly reduced thiobarbituric acid reactive substances levels, suggesting improved antioxidant status and reduced lipid peroxidation. These findings show that Eclipta alba mitigates Alzheimer’s disease-associated cognitive deficits, likely through its antioxidative activity. Although this is a preliminary study, further studies are required to fully establish the neuroprotective potential of Eclipta alba and its suitability for clinical applications.