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<p>Plant-based therapeutics are increasingly studied as alternatives or add-ons to conventional antiepileptic medications. <i>Bauhinia variegata</i> is a&#xa0;medicinal plant used in traditional medicine and is reported to exhibit antioxidant and neuroprotective properties. In this study, fresh leaves of <i>B.&#xa0;variegata </i>were collected, authenticated, shade-dried, coarsely powdered, and extracted using a&#xa0;hydroalcoholic solvent system (ethanol:water, 6:4) via Soxhlet extraction, then dried under vacuum and lyophilized. The hydroalcoholic extract of <i>B.&#xa0;variegata</i> leaves was prepared and used for qualitative phytochemical tests and GC–MS analysis to identify major bioactive compounds. Anticonvulsant activity was tested in rats with the MES model, where animals received oral doses of the extract before electroshock-induced seizures. Preliminary phytochemical screening showed the presence of terpenoids, steroids, fatty acids, and antioxidant constituents. In the MES model, administering the hydroalcoholic extract significantly reduced seizure severity and/or prevented hind-limb tonic extension compared with vehicle-treated controls, indicating effectiveness against generalized tonic-clonic seizures. The hydroalcoholic extract of <i>Bauhinia variegata</i> leaves shows promising antiepileptic activity in the MES rat model, likely due to its antioxidant and neuroprotective phytoconstituents. Further research is needed to isolate active compounds, understand mechanisms (such as antioxidant activity and ion-channel modulation), and evaluate safety and dose-response relationships.</p>

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Phytochemical profiling and preliminary assessment of the antiepileptic activity of Bauhinia variegata leaves

  • 期刊论文

  • 发表日期：

    2024年3月1日

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  • Ritesh Singh,
  • Ashwani Kumar,
  • Vaishali Dobhal,
  • Saloni Kakkar,
  • Falguni Goel,
  • Akash Tyagi,
  • Ishu Garg

摘要

Plant-based therapeutics are increasingly studied as alternatives or add-ons to conventional antiepileptic medications. Bauhinia variegata is a medicinal plant used in traditional medicine and is reported to exhibit antioxidant and neuroprotective properties. In this study, fresh leaves of B. variegata were collected, authenticated, shade-dried, coarsely powdered, and extracted using a hydroalcoholic solvent system (ethanol:water, 6:4) via Soxhlet extraction, then dried under vacuum and lyophilized. The hydroalcoholic extract of B. variegata leaves was prepared and used for qualitative phytochemical tests and GC–MS analysis to identify major bioactive compounds. Anticonvulsant activity was tested in rats with the MES model, where animals received oral doses of the extract before electroshock-induced seizures. Preliminary phytochemical screening showed the presence of terpenoids, steroids, fatty acids, and antioxidant constituents. In the MES model, administering the hydroalcoholic extract significantly reduced seizure severity and/or prevented hind-limb tonic extension compared with vehicle-treated controls, indicating effectiveness against generalized tonic-clonic seizures. The hydroalcoholic extract of Bauhinia variegata leaves shows promising antiepileptic activity in the MES rat model, likely due to its antioxidant and neuroprotective phytoconstituents. Further research is needed to isolate active compounds, understand mechanisms (such as antioxidant activity and ion-channel modulation), and evaluate safety and dose-response relationships.