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Purpose <p>To investigate the visual characteristics and prognosis of vision-threatening meningiomas following low dose head radiation and compare them to those of primary unexposed meningiomas.</p> Methods <p>A retrospective cohort of adults with meningiomas adjacent to the optic nerves or intracranial visual pathways was categorized into radiation-exposed and unexposed meningiomas. Data collected included demographics, visual biomarkers at presentation and at final follow-up, including Visual Acuity (VA), color vision (CV), Visual Field (VF) and peripapillary Retinal Nerve Fiber Layer (RNFL) thickness via Optical coherence tomography (OCT). Comparative analyses were performed between radiation-exposed and unexposed cohorts.</p> Results <p>289 eligible patients seen between 2004 and 2023 were included, out of which 31 (10.7%) had undergone tinea capitis radiation. At presentation, patients exhibited a median BCVA of 0.1 LogMAR [IQR 0.1–0.6], median CV of 100% [IQR 64.5%-100%], and 9 (29%) had normal visual fields. Notably, 16 (51.61%) experienced visual loss. Their BCVA decreased at final follow-up, to median 0.23 [IQR 0.1–1.46]. Comparative analysis with 114 radiation-naïve patients with meningioma-induced visual loss revealed no statistically significant disparities in visual characteristics at presentation or at follow-up.</p> Conclusions <p>No statistically significant differences in clinical presentation or visual prognosis were detected between patients with visual pathway meningiomas exposed to low-dose childhood radiation and radiation-naïve patients. Since low-dose cranial irradiation continues to be widely used for conditions such as thyroid eye disease, our findings are relevant beyond the specific context of tinea capitis.</p>

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Visual outcomes of sight threatening radiation-induced meningiomas after low-dose head irradiation: tinea capitis as a paradigm

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月7日

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  • Dahlia Palevski,
  • Hadas Stiebel-Kalish,
  • Omer Yizhach Bialer

摘要

Purpose

To investigate the visual characteristics and prognosis of vision-threatening meningiomas following low dose head radiation and compare them to those of primary unexposed meningiomas.

Methods

A retrospective cohort of adults with meningiomas adjacent to the optic nerves or intracranial visual pathways was categorized into radiation-exposed and unexposed meningiomas. Data collected included demographics, visual biomarkers at presentation and at final follow-up, including Visual Acuity (VA), color vision (CV), Visual Field (VF) and peripapillary Retinal Nerve Fiber Layer (RNFL) thickness via Optical coherence tomography (OCT). Comparative analyses were performed between radiation-exposed and unexposed cohorts.

Results

289 eligible patients seen between 2004 and 2023 were included, out of which 31 (10.7%) had undergone tinea capitis radiation. At presentation, patients exhibited a median BCVA of 0.1 LogMAR [IQR 0.1–0.6], median CV of 100% [IQR 64.5%-100%], and 9 (29%) had normal visual fields. Notably, 16 (51.61%) experienced visual loss. Their BCVA decreased at final follow-up, to median 0.23 [IQR 0.1–1.46]. Comparative analysis with 114 radiation-naïve patients with meningioma-induced visual loss revealed no statistically significant disparities in visual characteristics at presentation or at follow-up.

Conclusions

No statistically significant differences in clinical presentation or visual prognosis were detected between patients with visual pathway meningiomas exposed to low-dose childhood radiation and radiation-naïve patients. Since low-dose cranial irradiation continues to be widely used for conditions such as thyroid eye disease, our findings are relevant beyond the specific context of tinea capitis.