Scholarlink

Purpose <p>Among oligodendrogliomas, World Health Organization (WHO) grade 2 tumors have relatively more favorable prognosis compared to the grade 3. However, heterogeneity in tumoral behavior exists in grade 2 oligodendrogliomas, with some exhibiting an aggressive course. The authors applied [<sup>18</sup>F]FET-PET in oligodendrogliomas and extended its utility in predicting prognosis of low-grade oligodendrogliomas.</p> Methods <p>Twelve consecutive patients with oligodendrogliomas treated at our institution (Oligo-WHO2: <i>n</i> = 8; Oligo-WHO3: <i>n</i> = 4) were enrolled. All patients underwent contrast-enhanced MRI and [<sup>18</sup>F]FET-PET/MR before surgery. Maximum and mean target-to-background ratios (TBRmax, TBRmean) were evaluated, and progression-free survival (PFS) was recorded. Bulk RNA sequencing and immunohistochemical(IHC) staining were performed for the verification of [<sup>18</sup>F]FET-PET findings.</p> Results <p>All grade-3 oligodendrogliomas presented high [<sup>18</sup>F]FET uptake on PET and contrast-enhancement on MRI. Although all grade-2 tumors were non-enhanced, only 50% showed low uptake of [<sup>18</sup>F]FET, which thus dissected grade-2 oligodendrogliomas into two subgroups: Oligo-WHO2-Low-Uptake and Oligo-WHO2-High-Uptake tumors. Using cutoff of TBRmax = 2.5, [<sup>18</sup>F]FET-PET based stratification was more correlated with PFS, compared to the WHO grade classification, with all of 4 recurrent oligodendrogliomas (2/4 were grade-2) being [<sup>18</sup>F]FET high-uptake. Transcriptional results revealed clear discrimination: Oligo-WHO2-High-Uptake tumors were enriched with pathways of energy metabolism and tumor chemotaxis, while the Oligo-WHO2-High-Uptake group displayed upregulation of myelin formation-related pathways. Representative protein markers were selected for validation, with IHC staining unveiling AK4, CXCL5, and IL-33 highly expressed in Oligo-WHO2-High-Uptake oligodendrogliomas and SOX10 enriched in Oligo-WHO2-Low-Uptake tumors.</p> Conclusion <p>WHO grade 2 oligodendrogliomas is a heterogeneous composition of tumors with distinct prognosis and molecular characteristics. [<sup>18</sup>F]FET-PET represents a promising radiological tool for dissecting these tumors.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

[18F]FET-PET in dissecting low-grade oligodendrogliomas

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月20日

查看全文
  • Jiahui Liu,
  • Qingqing Han,
  • Wenbo Wu,
  • Hai Wang,
  • Xiaona Li,
  • Kun Zheng,
  • Dachun Zhao,
  • Wenbin Ma,
  • Xin Cheng,
  • Xiaopeng Guo,
  • Li Huo,
  • Yu Wang

摘要

Purpose

Among oligodendrogliomas, World Health Organization (WHO) grade 2 tumors have relatively more favorable prognosis compared to the grade 3. However, heterogeneity in tumoral behavior exists in grade 2 oligodendrogliomas, with some exhibiting an aggressive course. The authors applied [18F]FET-PET in oligodendrogliomas and extended its utility in predicting prognosis of low-grade oligodendrogliomas.

Methods

Twelve consecutive patients with oligodendrogliomas treated at our institution (Oligo-WHO2: n = 8; Oligo-WHO3: n = 4) were enrolled. All patients underwent contrast-enhanced MRI and [18F]FET-PET/MR before surgery. Maximum and mean target-to-background ratios (TBRmax, TBRmean) were evaluated, and progression-free survival (PFS) was recorded. Bulk RNA sequencing and immunohistochemical(IHC) staining were performed for the verification of [18F]FET-PET findings.

Results

All grade-3 oligodendrogliomas presented high [18F]FET uptake on PET and contrast-enhancement on MRI. Although all grade-2 tumors were non-enhanced, only 50% showed low uptake of [18F]FET, which thus dissected grade-2 oligodendrogliomas into two subgroups: Oligo-WHO2-Low-Uptake and Oligo-WHO2-High-Uptake tumors. Using cutoff of TBRmax = 2.5, [18F]FET-PET based stratification was more correlated with PFS, compared to the WHO grade classification, with all of 4 recurrent oligodendrogliomas (2/4 were grade-2) being [18F]FET high-uptake. Transcriptional results revealed clear discrimination: Oligo-WHO2-High-Uptake tumors were enriched with pathways of energy metabolism and tumor chemotaxis, while the Oligo-WHO2-High-Uptake group displayed upregulation of myelin formation-related pathways. Representative protein markers were selected for validation, with IHC staining unveiling AK4, CXCL5, and IL-33 highly expressed in Oligo-WHO2-High-Uptake oligodendrogliomas and SOX10 enriched in Oligo-WHO2-Low-Uptake tumors.

Conclusion

WHO grade 2 oligodendrogliomas is a heterogeneous composition of tumors with distinct prognosis and molecular characteristics. [18F]FET-PET represents a promising radiological tool for dissecting these tumors.