Scholarlink

Purpose <p>Breast cancer (BC) is the most frequent cancer among women and the second leading cause of central nervous system (CNS) metastases. While the epidemiology of CNS metastases from BC has been well described, little is known about the treatment patterns and outcomes of young women &lt; 40 years of age with BC that is metastatic to the CNS.</p> Methods <p>In this retrospective analysis, we identified patients with metastatic breast cancer (MBC) to the CNS who were treated at the Sunnybrook Odette Cancer Center, Toronto, Canada between 2008 and 2018. Young women were defined as those who were &lt; 40 years of age at the time of diagnosis of CNS metastases. Descriptive statistics were completed, and survival analyses performed.</p> Results <p>Similar clinical and pathological characteristics were observed among young and older women with CNS metastases. However, young women were significantly more likely to develop leptomeningeal metastatic disease (LMD) than older women (39.6% vs. 22.3%, <i>p</i> = 0.004). Additionally, young women were significantly more likely to be re-treated for CNS metastases (43.4% vs. 24.5%, <i>p</i> = 0.003). There was no significant difference in median brain-specific progression-free survival (bs-PFS) (log-rank <i>p</i> = 0.35) or overall survival (OS) (log-rank <i>p</i> value = 0.52) between young and older women.</p> Conclusions <p>Women &lt; 40 years of age were more likely to develop LMD than women ≥ 40 years of age. Although young women were also more likely to be re-treated for progression of CNS metastases, their bs-PFS and OS were not inferior to those ≥ 40 years of age.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinical–pathological patterns and prognosis of young women with breast cancer brain metastases: a single-center retrospective study

  • 期刊论文

  • 发表日期：

    2025年9月9日

查看全文
  • Isabella Kojundzic,
  • Jamie Lee Fritz,
  • Badr Id Said,
  • Sandy Vuong,
  • Hany Soliman,
  • Marguerite Ennis,
  • Ellen Warner,
  • Katarzyna Joanna Jerzak

摘要

Purpose

Breast cancer (BC) is the most frequent cancer among women and the second leading cause of central nervous system (CNS) metastases. While the epidemiology of CNS metastases from BC has been well described, little is known about the treatment patterns and outcomes of young women < 40 years of age with BC that is metastatic to the CNS.

Methods

In this retrospective analysis, we identified patients with metastatic breast cancer (MBC) to the CNS who were treated at the Sunnybrook Odette Cancer Center, Toronto, Canada between 2008 and 2018. Young women were defined as those who were < 40 years of age at the time of diagnosis of CNS metastases. Descriptive statistics were completed, and survival analyses performed.

Results

Similar clinical and pathological characteristics were observed among young and older women with CNS metastases. However, young women were significantly more likely to develop leptomeningeal metastatic disease (LMD) than older women (39.6% vs. 22.3%, p = 0.004). Additionally, young women were significantly more likely to be re-treated for CNS metastases (43.4% vs. 24.5%, p = 0.003). There was no significant difference in median brain-specific progression-free survival (bs-PFS) (log-rank p = 0.35) or overall survival (OS) (log-rank p value = 0.52) between young and older women.

Conclusions

Women < 40 years of age were more likely to develop LMD than women ≥ 40 years of age. Although young women were also more likely to be re-treated for progression of CNS metastases, their bs-PFS and OS were not inferior to those ≥ 40 years of age.