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Introduction <p>Elderly patients with IDH-wild type glioblastoma (IDH-WT GBM) have a dismal prognosis compared to younger patients. Given the prognostic relevance of extent of resection (EOR), we aimed to assess the prognostic utility of the Response Assessment in Neuro-Oncology (RANO)-<i>resect</i> classification in this population.</p> Methods <p>We retrospectively analyzed patients ≥ 65 years who underwent resection for newly diagnosed IDH-WT GBM between 2005 and 2023. EOR was categorized per RANO-<i>resect</i> classifications based on volumetric MRI analysis.</p> Results <p>Among 147 patients, 54 (36.7%) had Class 1 and 2 resection, 70 (47.6%) had Class 3 resection, and 23 (15.6%) underwent biopsy. The incidence of postoperative neurological and non-neurological complications was comparable across RANO-<i>resect</i> classes. Median overall survival (OS) was significantly longer for Class 1 and 2 resection (16.0 months, 95% CI: 10.4–21.7) versus Class 3 (10.6 months, 95% CI: 9.1–12.1) and biopsy (8.8 months, 95% CI: 4.0–13.5) (<i>p</i> = 0.033). Progression-free survival (PFS) did not differ between groups. Notably, in the adjuvant chemoradiotherapy sensitivity analysis, categorical RANO-<i>resect</i> classes showed no OS differences, but residual CE tumor volume remained independently prognostic of OS (HR = 1.006; 95% CI: 1.001–1.010; <i>p</i> = 0.010).</p> Conclusion <p>While greater EOR within RANO-<i>resect</i> classes correlated with improved OS and similar safety, adjuvant chemoradiotherapy sensitivity analyses showed no categorical OS differences. However, residual CE tumor volume remained independently prognostic of survival. Further studies are needed to clarify the role of surgery in elderly IDH-WT GBM patients.</p>

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Assessment of the RANO-resect criteria in elderly patients with glioblastoma

  • 期刊论文

  • 发表日期：

    2025年7月31日

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  • Josh Bandopadhay,
  • Pavel S. Pichardo-Rojas,
  • Rhea Cho,
  • Elham Tavakkol,
  • Kamand Khalaj,
  • Andres Rodriguez,
  • Antonio Dono,
  • Roy Riascos,
  • Nitin Tandon,
  • Yoshua Esquenazi

摘要

Introduction

Elderly patients with IDH-wild type glioblastoma (IDH-WT GBM) have a dismal prognosis compared to younger patients. Given the prognostic relevance of extent of resection (EOR), we aimed to assess the prognostic utility of the Response Assessment in Neuro-Oncology (RANO)-resect classification in this population.

Methods

We retrospectively analyzed patients ≥ 65 years who underwent resection for newly diagnosed IDH-WT GBM between 2005 and 2023. EOR was categorized per RANO-resect classifications based on volumetric MRI analysis.

Results

Among 147 patients, 54 (36.7%) had Class 1 and 2 resection, 70 (47.6%) had Class 3 resection, and 23 (15.6%) underwent biopsy. The incidence of postoperative neurological and non-neurological complications was comparable across RANO-resect classes. Median overall survival (OS) was significantly longer for Class 1 and 2 resection (16.0 months, 95% CI: 10.4–21.7) versus Class 3 (10.6 months, 95% CI: 9.1–12.1) and biopsy (8.8 months, 95% CI: 4.0–13.5) (p = 0.033). Progression-free survival (PFS) did not differ between groups. Notably, in the adjuvant chemoradiotherapy sensitivity analysis, categorical RANO-resect classes showed no OS differences, but residual CE tumor volume remained independently prognostic of OS (HR = 1.006; 95% CI: 1.001–1.010; p = 0.010).

Conclusion

While greater EOR within RANO-resect classes correlated with improved OS and similar safety, adjuvant chemoradiotherapy sensitivity analyses showed no categorical OS differences. However, residual CE tumor volume remained independently prognostic of survival. Further studies are needed to clarify the role of surgery in elderly IDH-WT GBM patients.