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<p>Alzheimer’s disease (AD) is a neurodegenerative disorder with a progressive pattern of cognitive and behavioral impairments. Many vital cerebral processes, such as synaptic plasticity, calcium homeostasis, neurogenesis, glial and mitochondrial function, autophagy, and the balance of excitation and inhibition, are significantly impaired in AD. Spatial memory deficit is an early clinical sign of AD. Despite the abundance of studies on spatial memory, the mechanisms of impairment of fear memory at different stages of the development of AD remain poorly understood. The formation of associative fear memory, in which an animal develops protective reactions, is a necessity for survival in a constantly changing environment. This review presents experimental evidence of the main mechanisms of impairment of fear memory obtained in mice and rats in models of AD.</p>

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Neurophysiological and Molecular Mechanisms of Impairments to Fear Memory in Models of Alzheimer’s Disease

  • 期刊论文

  • 发表日期：

    2026年8月3日

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  • N. I. Dubrovina,
  • M. V. Ovsyukova,
  • V. Gao,
  • M. A. Tikhonova

摘要

Alzheimer’s disease (AD) is a neurodegenerative disorder with a progressive pattern of cognitive and behavioral impairments. Many vital cerebral processes, such as synaptic plasticity, calcium homeostasis, neurogenesis, glial and mitochondrial function, autophagy, and the balance of excitation and inhibition, are significantly impaired in AD. Spatial memory deficit is an early clinical sign of AD. Despite the abundance of studies on spatial memory, the mechanisms of impairment of fear memory at different stages of the development of AD remain poorly understood. The formation of associative fear memory, in which an animal develops protective reactions, is a necessity for survival in a constantly changing environment. This review presents experimental evidence of the main mechanisms of impairment of fear memory obtained in mice and rats in models of AD.