Scholarlink

<p>The glymphatic system, which mediates clearance of metabolites from the central nervous system, plays a key role in maintaining brain homeostasis, particularly during sleep. Disruption of its functioning caused by prolonged general anesthesia can lead to the development of persistent postoperative sleep disorders. This article provides a detailed examination of the pathophysiological mechanisms of this process, including suppression of aquaporin-4 activity, the development of oxidative stress and neuroinflammation, and disruption of neurovascular and circadian regulation. Particular attention is paid to the effects of anesthetics on the suprachiasmatic nucleus and melatonin secretion, which leads to disorganization of normal sleep architecture. The role of genetic factors, in particular the APOE4 allele, in increasing vulnerability to anesthetic effects is demonstrated. Chronotherapy with melatonin, antioxidants, and modulators of glymphatic function aimed at restoring physiological sleep patterns are seen as promising therapeutic approaches. These data highlight the need to develop personalized anesthetic management protocols taking account of impact on the glymphatic system and circadian rhythms to prevent postoperative chronopathological disorders.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Role of the Glymphatic System in the Development of Chronopathological Disorders in Patients after Surgery with Prolonged Anesthesia

  • 期刊论文

  • 发表日期：

    2026年8月3日

查看全文
  • O. A. Kicherova,
  • I. A. Kiprin,
  • L. I. Reikhert,
  • K. P. Kicherova,
  • T. E. Verbakh,
  • Y. I. Doyan,
  • A. V. Gorbachevsky,
  • V. A. Saltanova,
  • N. A. Mazurov

摘要

The glymphatic system, which mediates clearance of metabolites from the central nervous system, plays a key role in maintaining brain homeostasis, particularly during sleep. Disruption of its functioning caused by prolonged general anesthesia can lead to the development of persistent postoperative sleep disorders. This article provides a detailed examination of the pathophysiological mechanisms of this process, including suppression of aquaporin-4 activity, the development of oxidative stress and neuroinflammation, and disruption of neurovascular and circadian regulation. Particular attention is paid to the effects of anesthetics on the suprachiasmatic nucleus and melatonin secretion, which leads to disorganization of normal sleep architecture. The role of genetic factors, in particular the APOE4 allele, in increasing vulnerability to anesthetic effects is demonstrated. Chronotherapy with melatonin, antioxidants, and modulators of glymphatic function aimed at restoring physiological sleep patterns are seen as promising therapeutic approaches. These data highlight the need to develop personalized anesthetic management protocols taking account of impact on the glymphatic system and circadian rhythms to prevent postoperative chronopathological disorders.