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<p>Studies in a model of combined brain and spinal cord injury in Wistar rats showed that the NO content in the injured area of the left frontal lobe of the brain decreased significantly and consistently 24 h after injury. In the contralateral area of the brain (the right frontal lobe), a significant decrease in NO content relative to the level in the control group was also observed, though this was smaller in magnitude and not consistent. The observed decrease in NO content in the frontal lobe tissues of rats 24 h after combined brain and spinal cord injury replicated the reduced NO content in these tissues demonstrated in our previous study one week after the same injury. These results provide new information on the content of free NO in brain tissue damaged during combined brain injury for a period of one day to one week and open up opportunities for seeking new therapeutic methods.</p>

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Study of No Content in the Frontal Lobes of Rats 24 Hours after Combined Brain and Spinal Cord Injury

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • V. V. Andrianov,
  • I. B. Deryabina,
  • L. N. Muranova,
  • D. I. Silantyeva,
  • G. G. Yafarova,
  • L. V. Bazan,
  • T. Kh. Bogodvid,
  • A. I. Arslanov,
  • S. G. Pashkevich,
  • T. A. Filipovich,
  • V. A. Kulchitskiy,
  • Kh. L. Gainutdinov

摘要

Studies in a model of combined brain and spinal cord injury in Wistar rats showed that the NO content in the injured area of the left frontal lobe of the brain decreased significantly and consistently 24 h after injury. In the contralateral area of the brain (the right frontal lobe), a significant decrease in NO content relative to the level in the control group was also observed, though this was smaller in magnitude and not consistent. The observed decrease in NO content in the frontal lobe tissues of rats 24 h after combined brain and spinal cord injury replicated the reduced NO content in these tissues demonstrated in our previous study one week after the same injury. These results provide new information on the content of free NO in brain tissue damaged during combined brain injury for a period of one day to one week and open up opportunities for seeking new therapeutic methods.