<p>The mediobasal segments of the temporal lobe (MBTL) play a vital role in cognitive processes in humans, including memory. However, systemic functional changes in the brain associated with MBTL tumors have received insufficient study, particularly in the context of the lateralization of memory. The aim of the present study was to identify the neurodynamic characteristics of visual memorization (VM) associated with mediobasal temporal lobe tumors in the right or left hemisphere of the brain in humans. The study included 24 patients with meningioma of the MBTL (13 left-sided (grLT) and 11 right-sided (grRT)) and nine healthy volunteers. The study included analysis of EEG coherence (CohEEG) and fMRI activation during VM, as well as neuropsychological assessment of memory performance. In normal conditions, VM was found to be accompanied by 1) an increase in θ1 CohEEG compared to baseline in the left frontotemporal region and 2) variable fMRI activation – focal in the right occipitocerebellar region or more diffuse, involving the bilateral frontobasal and parietal-temporal regions. In the grLT, a selective decrease in θ1/α2 CohEEG was detected on VM, with preserved left-hemisphere frontotemporal reactivity, as well as variable fMRI activation – from activation located in the right hemisphere to widespread bilateral activation. Patients in the grRT were characterized by a generalized bilateral decrease in CohEEG (especially in the α2 range), with dominance of the frontotemporal and occipitoparietal loci, which correlated with diffuse bilateral fMRI activation. Despite significant neurophysiological changes on VM, there were no differences in neuropsychological test indicators between all observation groups, which probably reflects the effect of compensatory neuroplasticity with different strategies for the functional reorganization of the brain depending on the lateralization of the lesion.</p>