<p><b>Objective.</b> To determine the potential for using an original method for video analysis of facial expression as an aid in the diagnosis of Alzheimer’s disease. <b>Materials and methods.</b> The study included a group of healthy individuals (<i>n</i> = 37) and a group of patients (<i>n</i> = 34) with neurocognitive disorder (NCD) due to Alzheimer’s disease. The group of patients was divided into subgroups of those with “minor” NCD (<i>n</i> = 16) and those with “major” NCD (<i>n</i> = 18). The method is based on the recording of 68 key facial points using a contactless method. Analysis of kinetic indexes of eyebrow, eyelid, and mouth movements was conducted as part of the following diagnostic tests: “Smile,” “Making the letter ‘O’ with the lips,” “Blinking,” “Raising eyebrows,” “Frowning,” and “Reading text.” <b>Results.</b> Comparison of healthy individuals with the group of patients in terms of the resulting data on the state of facial expressions revealed a statistically significant differences (<i>p</i> &lt; 0.05) in the amplitude and speed indexes of eyebrow, eyelid, and mouth movements. Statistically significant differences (<i>p</i> &lt; 0.05) were also found between the two subgroups of patients with NCD in terms of indexes such as “smile frequency,” “eyebrow raising frequency,” and “amplitude of eyebrow raising along the X-axis.” As compared with those with “minor” NCD, patients in the subgroup with “major” NCD showed a lower amplitude of eyebrow raising along the X-axis and a smaller frequency of raising by factors of approximately two, along with a 1.6-fold decrease in the frequency of smiling. <b>Conclusion.</b> The method has promise as a screening and adjunctive diagnostic tool in patients with suspected Alzheimer’s disease. Further study of the technique to determine its diagnostic value is required.</p>