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<p>Trace amines and their receptors, in particular trace amine-associated receptor 9 (TAAR9), can act as potential regulators of the mechanisms of compulsivity and impulsivity as manifestations of addictive behavior. The aim of the present work was to evaluate the impulsive and compulsive components of the behavioral phenotype of TAAR9 knockout rats. Impulsive elements in behavior were assessed using an adapted Iowa Gambling Task (IGT). TAAR9-KO rats showed no differences from wild-type rats in the IGT test and displayed equal preference for the option associated with the greatest reward. The marble burying test was used to assess the compulsive component of behavior. The TAAR9-KO group demonstrated an increase in compulsive-like behavior as compared with controls in the marble burying test. Thus, TAAR9-knockout rats demonstrated the prerequisites for increased compulsive behavior, which is associated with the development of elements of gambling addiction.</p>

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Assessment of Impulsivity and Compulsivity in TAAR9 Knockout Rats Using an Addictive Behavior Model

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • D. V. Surov,
  • A. A. Lebedev,
  • S. S. Pyurveev,
  • I. S. Zhukov,
  • K. E. Gramota,
  • D. S. Traktirov,
  • P. D. Shabanov

摘要

Trace amines and their receptors, in particular trace amine-associated receptor 9 (TAAR9), can act as potential regulators of the mechanisms of compulsivity and impulsivity as manifestations of addictive behavior. The aim of the present work was to evaluate the impulsive and compulsive components of the behavioral phenotype of TAAR9 knockout rats. Impulsive elements in behavior were assessed using an adapted Iowa Gambling Task (IGT). TAAR9-KO rats showed no differences from wild-type rats in the IGT test and displayed equal preference for the option associated with the greatest reward. The marble burying test was used to assess the compulsive component of behavior. The TAAR9-KO group demonstrated an increase in compulsive-like behavior as compared with controls in the marble burying test. Thus, TAAR9-knockout rats demonstrated the prerequisites for increased compulsive behavior, which is associated with the development of elements of gambling addiction.