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<p>This article presents the epidemiology of stroke and dementia based on data from the Moscow region, the Russian Federation, Western Europe, and the USA. A brief review of the literature on primary progressive aphasia (PPA) is provided and the diagnostic criteria and main variants of the disease are described. Two clinical observations are presented: a patient with an agrammatic form of PPA and a patient with post-stroke aphasia. Results from studies of routine MRI, functional MRI with a speech paradigm, and diffusion tensor imaging with tractography are presented and the main differences in the clinical picture and MRI investigation results in cases with a similar clinical picture of motor aphasia caused by a neurodegenerative process and developing as a result of stroke are analyzed. Additional tests for early detection of the agrammatic form of PPA are given.</p>

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Primary Progressive Aphasia in Neurological Practice

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • S. V. Kotov,
  • M. M. Shcherbakova,
  • G. T. Tonya,
  • E. A. Stepanova,
  • E. V. Isakova,
  • V. A. Zenina

摘要

This article presents the epidemiology of stroke and dementia based on data from the Moscow region, the Russian Federation, Western Europe, and the USA. A brief review of the literature on primary progressive aphasia (PPA) is provided and the diagnostic criteria and main variants of the disease are described. Two clinical observations are presented: a patient with an agrammatic form of PPA and a patient with post-stroke aphasia. Results from studies of routine MRI, functional MRI with a speech paradigm, and diffusion tensor imaging with tractography are presented and the main differences in the clinical picture and MRI investigation results in cases with a similar clinical picture of motor aphasia caused by a neurodegenerative process and developing as a result of stroke are analyzed. Additional tests for early detection of the agrammatic form of PPA are given.