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<p>Parkinson’s disease (PD) is a complex neurodegenerative disorder characterised by motor and non-motor symptoms due to dopaminergic neuronal death. The study aimed to assess the motor and non-motor behaviour changes in PD patients using the Unified Parkinson’s Disease Rating Scale (UPDRS)—parts I and II, and evaluate the cognitive function changes using the Parkinson’s Disease Cognitive Function Rating Scale (PD-CFRS). The research obtained 133 Parkinson’s disease patients and 142 healthy control individuals from the hospital. Patients were evaluated during diagnosis and more than 60&#xa0;days after treatment with the PD-CFRS and MDS-UPDRS scales. IBM SPSS Statistics was utilised for various statistical calculations for descriptive statistics, paired sample <i>T</i>-tests, and hierarchical regression analysis. There were statistically significant changes in the scales MDS-UPDRS-I, MDS-UPDRS-II, and UPDRS-CF, as well as PD-CFRS scores, after treatment (<i>p</i> &lt; 0.001). The correlation between scales suggested that there was a positive correlation of UPDRS-II with both UPDRS-I and UPDRS-CF. Hierarchical regression reveals that age and gender had statistically significant relationships with PD-CFRS Treatment scores. In contrast, UPDRS-I and II had a positive and strong relationship with the mean scores of UPDRS-CF, irrespective of the treatment given. There is a strong link between motor and cognitive function impairments among PD patients, which raises the need to take both factors into account in the treatment of PD. The scores in UPDRS-I, UPDRS-II, and UPDRS-CF scales corresponded to the level of severity of the PD condition and treatment outcome.</p>

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The interplay between motor dysfunction and cognitive decline in Parkinson’s disease: insights from MDS-UPDRS and PD-CFRS assessments

  • 期刊论文

  • 发表日期：

    2026年1月17日

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  • Rohit,
  • Shamsher Singh

摘要

Parkinson’s disease (PD) is a complex neurodegenerative disorder characterised by motor and non-motor symptoms due to dopaminergic neuronal death. The study aimed to assess the motor and non-motor behaviour changes in PD patients using the Unified Parkinson’s Disease Rating Scale (UPDRS)—parts I and II, and evaluate the cognitive function changes using the Parkinson’s Disease Cognitive Function Rating Scale (PD-CFRS). The research obtained 133 Parkinson’s disease patients and 142 healthy control individuals from the hospital. Patients were evaluated during diagnosis and more than 60 days after treatment with the PD-CFRS and MDS-UPDRS scales. IBM SPSS Statistics was utilised for various statistical calculations for descriptive statistics, paired sample T-tests, and hierarchical regression analysis. There were statistically significant changes in the scales MDS-UPDRS-I, MDS-UPDRS-II, and UPDRS-CF, as well as PD-CFRS scores, after treatment (p < 0.001). The correlation between scales suggested that there was a positive correlation of UPDRS-II with both UPDRS-I and UPDRS-CF. Hierarchical regression reveals that age and gender had statistically significant relationships with PD-CFRS Treatment scores. In contrast, UPDRS-I and II had a positive and strong relationship with the mean scores of UPDRS-CF, irrespective of the treatment given. There is a strong link between motor and cognitive function impairments among PD patients, which raises the need to take both factors into account in the treatment of PD. The scores in UPDRS-I, UPDRS-II, and UPDRS-CF scales corresponded to the level of severity of the PD condition and treatment outcome.