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<p>This review reflects the main mechanisms of the pathogenesis of migraine from the point of view of its biochemical features (neurotransmitter metabolism, neurochemistry, neurophysiology, and neurogenetics). The influences of hormones, electrolytes (magnesium, calcium, sodium), vitamins (vitamins D, B12), and other biologically active molecules (melatonin, L-carnitine, L-tryptophan) on the course of the disease are considered. The inclusion of certain laboratory parameters in the diagnostic algorithm for migraine supports identification of the secondary nature of headache and/or dizziness, aiding approaches to management of therapy and adjustment of prognoses and treatment results.</p>

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Biochemical Features of the Pathogenesis of Migraine

  • 期刊论文

  • 发表日期：

    2025年9月11日

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  • N. L. Kunel’skaya,
  • Z. O. Zaoeva,
  • N. I. Vasilchenko,
  • M. A. Chugunova,
  • S. D. Revazishvili

摘要

This review reflects the main mechanisms of the pathogenesis of migraine from the point of view of its biochemical features (neurotransmitter metabolism, neurochemistry, neurophysiology, and neurogenetics). The influences of hormones, electrolytes (magnesium, calcium, sodium), vitamins (vitamins D, B12), and other biologically active molecules (melatonin, L-carnitine, L-tryptophan) on the course of the disease are considered. The inclusion of certain laboratory parameters in the diagnostic algorithm for migraine supports identification of the secondary nature of headache and/or dizziness, aiding approaches to management of therapy and adjustment of prognoses and treatment results.