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<p><b>Objective.</b> To study the characteristics and mechanisms of the development of oxidative stress in animal models on the background of sleep deprivation. <b>Materials and methods.</b> Experiments were conducted on 60 male rats aged six months, divided into three equal groups. Animals of the group 1 were intact, while chronic sleep deprivation by cyclic sleep restriction was modeled in those of groups 2 and 3. Animals of group 3 received standard diet supplemented with daily resveratrol (10 mg/kg, intragastrically). On experimental days 0, 1, 3, and 5, antioxidant enzyme activity and concentrations of peroxidation products in serum were assessed. <b>Results.</b> Sleep deprivation in animal models caused intensification of oxidative processes (increases in malondialdehyde and diene conjugate concentrations) and decreases in antioxidant enzyme activities (catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase). <b>Conclusions.</b> During sleep deprivation, highly toxic lipid peroxidation products accumulate in body tissues, leading to metabolic disorders and decreases in adaptive capacity. Supplementary administration of resveratrol helps to decrease the amplitude of fluctuations in the oxidation-reduction balance, which can be seen as a possible way to correct oxidative stress and prevent disorders associated with sleep restriction and disorders of the sleep–waking cycle.</p>

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Sleep Deprivation and the Development of Oxidative Stress in Animal Models

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • O. P. Bukareva,
  • O. N. Pavlova,
  • D. S. Gromova,
  • A. V. Zakharov,
  • I. V. Shirolapov

摘要

Objective. To study the characteristics and mechanisms of the development of oxidative stress in animal models on the background of sleep deprivation. Materials and methods. Experiments were conducted on 60 male rats aged six months, divided into three equal groups. Animals of the group 1 were intact, while chronic sleep deprivation by cyclic sleep restriction was modeled in those of groups 2 and 3. Animals of group 3 received standard diet supplemented with daily resveratrol (10 mg/kg, intragastrically). On experimental days 0, 1, 3, and 5, antioxidant enzyme activity and concentrations of peroxidation products in serum were assessed. Results. Sleep deprivation in animal models caused intensification of oxidative processes (increases in malondialdehyde and diene conjugate concentrations) and decreases in antioxidant enzyme activities (catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase). Conclusions. During sleep deprivation, highly toxic lipid peroxidation products accumulate in body tissues, leading to metabolic disorders and decreases in adaptive capacity. Supplementary administration of resveratrol helps to decrease the amplitude of fluctuations in the oxidation-reduction balance, which can be seen as a possible way to correct oxidative stress and prevent disorders associated with sleep restriction and disorders of the sleep–waking cycle.