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<p>We report here the first research into the specificity of the frequency effects of release from stimulus-specific adaptation in the activity of single neurons in the primary fields of the auditory cortex of house mice in the awake state. After adaptation of neuronal responses to sounds using sequences of four identical tones, adult females were presented with a fifth – deviant – tone signal, whose frequency differed from the frequency of the first four tone pulses of the series. This led to complete or partial release of neuronal responses from adaptation in the response to the fifth component of the sequence, i.e., the response to the fifth tone was significantly greater than the responses to the second through fourth tones. The effect of release from stimulus-specific adaptation was enhanced by locating the frequencies of the main tone sequence and the deviant tone in two non-overlapping critical bands of hearing in mice. Thus, these studies confirm the involvement of the critical band mechanism in enhancing the novelty responses of auditory neurons in the midbrain and auditory cortex.</p>

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The Role of Auditory Critical Bands in Stimulus-Specific Adaptation in the Spike Activity of Primary Auditory Cortex Neurons in Awake Mice

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • M. A. Egorova,
  • A. G. Akimov,
  • G. D. Khorunzhii

摘要

We report here the first research into the specificity of the frequency effects of release from stimulus-specific adaptation in the activity of single neurons in the primary fields of the auditory cortex of house mice in the awake state. After adaptation of neuronal responses to sounds using sequences of four identical tones, adult females were presented with a fifth – deviant – tone signal, whose frequency differed from the frequency of the first four tone pulses of the series. This led to complete or partial release of neuronal responses from adaptation in the response to the fifth component of the sequence, i.e., the response to the fifth tone was significantly greater than the responses to the second through fourth tones. The effect of release from stimulus-specific adaptation was enhanced by locating the frequencies of the main tone sequence and the deviant tone in two non-overlapping critical bands of hearing in mice. Thus, these studies confirm the involvement of the critical band mechanism in enhancing the novelty responses of auditory neurons in the midbrain and auditory cortex.