The Glymphatic System, Sleep, and Neurodegeneration

The prevalence of neurodegenerative diseases and the complexity of their treatment in the late stages make it important to identify early markers and symptoms of this group of diseases in order to optimize diagnosis, treatment, and prevention. Materials and methods. The PubMed database was analyzed using the following queries: perivascular space, Virchow–Robin space, glymphatic system, sleep disorders, and Alzheimer’s disease. Conclusions. Expansion of perivascular spaces [Virchow–Robin] can be regarded as an early structural marker of both glymphatic dysfunction and neurodegenerative diseases, while sleep disorders can be seen as a functional marker (symptom) of these disorders.