Exploring the thermodynamics of protein aggregation: an insight to Huntington's disease therapeutics

Huntington's disease (HD) stands as a formidable challenge in modern medicine, characterized by progressive neurodegeneration and cognitive decline. A hallmark feature of HD pathology is the aggregation of mutant huntingtin protein (mHTT), leading to cellular dysfunction and eventual neuronal demise. Despite extensive research, therapeutic interventions for HD remain elusive. This article delves into the intricate thermodynamics underlying protein aggregation in HD, exploring key molecular mechanisms and potential therapeutic avenues. By comprehensively elucidating the thermodynamic principles governing mHTT aggregation, novel insights can be garnered to inform the development of effective therapeutic strategies.

Clinical Trial: No clinical trial.