<p>Herein, nitrogen-doped fullerene C60-modified Bi₂S₃ nanorods (NC60/Bi₂S₃) hybrid catalysts were assembled via hydrothermal technique. The piezo-photocatalytic degradation efficiencies of synthesized xwt%-NC60/Bi₂S₃ (x = 0.5 to 3) were explored toward lomefloxacin (LFX). Under visible-lighting/ultrasonication, the 1.5wt%-NC60/Bi₂S₃ sample possesses higher piezo-photocatalytic degradation performance, where the apparent LFX degradation rate reached 0.078 min⁻¹ (97.6% degradation efficiency after 50 min), compared to 0.02 min⁻¹ and 0.065 min⁻¹ for piezocatalytic and photocatalytic, respectively, achieving a synergy percent of 67%. The boosted degradation activity and high stability of the developed NC60/Bi₂S₃ hybrid were attributed to the accelerated transfer of photogenerated electrons by NC60 as well as the induced piezoelectric effects by Bi₂S₃ nanorods. The separation pathway of photocharge carriers was investigated through trapping processes, which showed that mainly ^•O₂⁻ and secondarily h⁺ were the most contributing degradation species.</p> Graphical Abstract <p></p>