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<p>Microelectromechanical systems (MEMS)-based microfluidic cantilevers have emerged as a highly versatile platform for biosensing and biomedical diagnostics applications due to their inherent advantages, including real-time detection capabilities, compact size, and cost-effectiveness. However, enhancing the sensitivity and selectivity of current biosensors is essential for effective real-time detection applications. This study investigates a novel approach to enhance the sensitivity of MEMS-based microfluidic cantilever biosensors by leveraging magnetic interactions within the sensing microfluidic channel. The magnetic microfluid solutions with Fe₃O₄@PVP particles were prepared at different concentrations (5 µg/mL, 10 µg/mL, 50 µg/mL, and 100 µg/mL) and injected into microfluidic channels with a volume of approximately 40 picolitre (pL), embedded within MEMS microcantilevers. To assess the effect of the magnetic field on the dynamic mechanical properties of the injected microfluidic cantilevers, the resonance frequency and quality factor were determined before and during exposure to a magnetic field of 800 Gauss (0.08 T). The results revealed that exposure to the magnetic field caused a shift in the resonance frequency (Δf) by 21 ± 3 Hz for the microfluidic cantilever injected with the microfluid with the highest concentration (100 µg/mL) of Fe₃O₄@PVP magnetic particles. Simultaneously, the quality factor declined from 38.6 ± 0.3 to 36.6 ± 0.1 before and after exposure to the external magnetic field, respectively. These findings confirm that magnetic-field-enhanced MEMS microfluidic cantilevers can detect magnetic interactions with high sensitivity at the picolitre scale, offering a promising pathway for high-sensitivity biosensors in biomedical and environmental applications.</p> Graphical Abstract <p></p>

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MEMS-based microfluidic-assisted magnetic field biosensor for characterizing picolitre magnetic microfluid

  • 期刊论文

  • 发表日期：

    2026年3月22日

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  • Adham Aleid,
  • Mahmoud Al-Gawati,
  • Wed Jasser Almuhaideb,
  • Reem Adel Alhamdan,
  • L. Y. Beaulieu,
  • Muthumareeswaran Muthuramamoorthy,
  • Shofiur Rahman,
  • Abdullah N. Alodhayb

摘要

Microelectromechanical systems (MEMS)-based microfluidic cantilevers have emerged as a highly versatile platform for biosensing and biomedical diagnostics applications due to their inherent advantages, including real-time detection capabilities, compact size, and cost-effectiveness. However, enhancing the sensitivity and selectivity of current biosensors is essential for effective real-time detection applications. This study investigates a novel approach to enhance the sensitivity of MEMS-based microfluidic cantilever biosensors by leveraging magnetic interactions within the sensing microfluidic channel. The magnetic microfluid solutions with Fe₃O₄@PVP particles were prepared at different concentrations (5 µg/mL, 10 µg/mL, 50 µg/mL, and 100 µg/mL) and injected into microfluidic channels with a volume of approximately 40 picolitre (pL), embedded within MEMS microcantilevers. To assess the effect of the magnetic field on the dynamic mechanical properties of the injected microfluidic cantilevers, the resonance frequency and quality factor were determined before and during exposure to a magnetic field of 800 Gauss (0.08 T). The results revealed that exposure to the magnetic field caused a shift in the resonance frequency (Δf) by 21 ± 3 Hz for the microfluidic cantilever injected with the microfluid with the highest concentration (100 µg/mL) of Fe₃O₄@PVP magnetic particles. Simultaneously, the quality factor declined from 38.6 ± 0.3 to 36.6 ± 0.1 before and after exposure to the external magnetic field, respectively. These findings confirm that magnetic-field-enhanced MEMS microfluidic cantilevers can detect magnetic interactions with high sensitivity at the picolitre scale, offering a promising pathway for high-sensitivity biosensors in biomedical and environmental applications.

Graphical Abstract