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<p>Glutamate-induced toxicity in neuronal cells plays a crucial role in the development of neurodegenerative diseases, emphasizing the need for effective neuroprotective agents. Diosmin, a flavonoid known for its antioxidant and anti-inflammatory effects, has demonstrated the ability to shield cells from the harmful effects of glutamate. However, its low bioavailability and stability limit its therapeutic potential. In this research, we created selenium nanoparticles containing diosmin and stabilized by chitosan, aiming to boost their neuroprotective properties against glutamate-induced toxicity in PC12 cells. We hypothesized that the synergistic combination of diosmin, SeNPs, and chitosan would improve stability, bioavailability, and cellular uptake, enhancing neuroprotection. This investigation provides insights into the potential therapeutic application of diosmin-loaded SeNPs stabilized by chitosan in neuroprotection, highlighting the role of nanotechnology-based drug delivery systems in mitigating neurotoxicity. Ultimately, this study could potentially result in the creation of new approaches for managing neurodegenerative disorders.</p>

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Enhancement of the protective effect of diosmin against glutamate-induced toxicity by selenium-chitosan nanoparticle formulation

  • 期刊论文

  • 发表日期：

    2025年10月4日

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  • Elham Einafshar,
  • Tania Jafarzadeh,
  • Hossein Javid,
  • Hamed Amiri,
  • Hossein Hosseini

摘要

Glutamate-induced toxicity in neuronal cells plays a crucial role in the development of neurodegenerative diseases, emphasizing the need for effective neuroprotective agents. Diosmin, a flavonoid known for its antioxidant and anti-inflammatory effects, has demonstrated the ability to shield cells from the harmful effects of glutamate. However, its low bioavailability and stability limit its therapeutic potential. In this research, we created selenium nanoparticles containing diosmin and stabilized by chitosan, aiming to boost their neuroprotective properties against glutamate-induced toxicity in PC12 cells. We hypothesized that the synergistic combination of diosmin, SeNPs, and chitosan would improve stability, bioavailability, and cellular uptake, enhancing neuroprotection. This investigation provides insights into the potential therapeutic application of diosmin-loaded SeNPs stabilized by chitosan in neuroprotection, highlighting the role of nanotechnology-based drug delivery systems in mitigating neurotoxicity. Ultimately, this study could potentially result in the creation of new approaches for managing neurodegenerative disorders.