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<p>The pH-responsive second near infrared window (NIR-II) probes, used at the subcellular range, are unfrequent. Here, we designed and synthesized the NIR-II fluorescence probes ETN and mPE-NPS with significant pH response property and unique fluorescence mutation range (pH 4.5–5.0). It was worth noting that the mPE-NPS probe exhibited favorable biocompatibility and excellent NIR-II tumor cellular imaging capability, which is expected to be used for specific NIR-II fluorescence imaging of subcellular structures.</p> Graphical abstract <p></p>

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Construction of pH-mutation responsive NIR-II fluorophore for imaging of tumor cells

  • 期刊论文

  • 发表日期：

    2025年7月28日

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  • Xinxin Wu,
  • Yang Wang,
  • Yuyou Huang,
  • Jiayun Xu,
  • Quan Cheng

摘要

The pH-responsive second near infrared window (NIR-II) probes, used at the subcellular range, are unfrequent. Here, we designed and synthesized the NIR-II fluorescence probes ETN and mPE-NPS with significant pH response property and unique fluorescence mutation range (pH 4.5–5.0). It was worth noting that the mPE-NPS probe exhibited favorable biocompatibility and excellent NIR-II tumor cellular imaging capability, which is expected to be used for specific NIR-II fluorescence imaging of subcellular structures.

Graphical abstract