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<p>Gold nanoclusters (AuNCs) are among the most stable nanoclusters and are nanomaterials with a particle size of approximately 2&#xa0;nm. AuNCs have demonstrated considerable potential in the biomedical field due to their distinctive optical properties and exceptional biocompatibility. In this paper, two bifunctional peptides were designed and synthesised, comprising a domain with cell-penetrating peptide sequences and a domain with the capacity to biomineralise and capture Au clusters. Two novel peptide-AuNCs were synthesised using a one-step reduction method via bifunctional peptides. The impact of varying peptide/HAuCl<sub>4</sub> ratios on the nanocluster structure and fluorescence characteristics was investigated. The findings indicate that the peptide ratio influences the fluorescence colour of the nanoclusters. And as the proportion increases, nanoclusters tend to form a ligand pattern.</p> Graphical Abstract <p></p>

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Synthesis of gold nanoclusters mediated by bifunctional peptides and their self-assembly behaviour under proportional regulation

  • 期刊论文

  • 发表日期：

    2025年5月21日

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  • Yexi Zhang,
  • Huiye Liu,
  • Dongzhao Hao,
  • Chuanmei Tang,
  • Lei Yue,
  • Rongxin Su,
  • Wei Qi,
  • Xuemei Zhang,
  • Yuefei Wang

摘要

Gold nanoclusters (AuNCs) are among the most stable nanoclusters and are nanomaterials with a particle size of approximately 2 nm. AuNCs have demonstrated considerable potential in the biomedical field due to their distinctive optical properties and exceptional biocompatibility. In this paper, two bifunctional peptides were designed and synthesised, comprising a domain with cell-penetrating peptide sequences and a domain with the capacity to biomineralise and capture Au clusters. Two novel peptide-AuNCs were synthesised using a one-step reduction method via bifunctional peptides. The impact of varying peptide/HAuCl4 ratios on the nanocluster structure and fluorescence characteristics was investigated. The findings indicate that the peptide ratio influences the fluorescence colour of the nanoclusters. And as the proportion increases, nanoclusters tend to form a ligand pattern.

Graphical Abstract