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<p>In the face of the growth of the multi-resistant bacteria, the search for the effective antibacterial agents has become one of the main challenges of the modern society. Silver nanoparticles are known to be effective antibacterial agents, but their use is associated with the risk of the toxic effects on the mammalian cells. Therefore, it is essential to synthesize the silver nanoparticles that are stabilized by the low-toxic capping agents. In this study, we used a low-toxic carboxybetaine derivative of tetrapentylcalix[4]resorcine (C<sub>5</sub>-CB) as a capping agent for AgNPs. It is found that the syntheses of the AgNPs resulted in the formation of the nanocolloids (NCs) containing silver nanoparticles, stabilized by the C<sub>5</sub>-CB, and the complexes of the silver ions and the C<sub>5</sub>-CB. The NCs are characterized by the absorption spectroscopy, DLS, XRPD, TEM, IR, and TGA/DSC methods. It is shown that an Ag<sup>+</sup>/C<sub>5</sub>-CB molar ratio affects the size of the NCs and the AgNPs, their stability, antimicrobial activity, and cytotoxicity. The NCs exhibit bacteriostatic activity against strains of <i>Staphylococcus aureus</i> with multiple drug resistance (<i>MRSA-1</i> and <i>MRSA-2</i>) as well as a bactericidal activity (against <i>Sa</i>, <i>Ef</i>, and <i>Ec</i>) and a fungicidal activity (against <i>Ca</i>).</p> Graphical Abstract <p></p>

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The synthesis, spectral, structural and antimicrobial properties of nanocolloids of carboxybetaine calix[4]resorcine with silver nanoparticles and silver ions

  • 期刊论文

  • 发表日期：

    2025年5月7日

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  • Z. R. Gilmullina,
  • A. T. Kamaleeva,
  • A. P. Lyubina,
  • A. A. Parfenov,
  • A. D. Voloshina,
  • I. R. Nizameev,
  • J. E. Morozova,
  • A. Yu. Ziganshina,
  • D. V. Zakharychev,
  • A. T. Gubaidullin,
  • I. S. Antipin

摘要

In the face of the growth of the multi-resistant bacteria, the search for the effective antibacterial agents has become one of the main challenges of the modern society. Silver nanoparticles are known to be effective antibacterial agents, but their use is associated with the risk of the toxic effects on the mammalian cells. Therefore, it is essential to synthesize the silver nanoparticles that are stabilized by the low-toxic capping agents. In this study, we used a low-toxic carboxybetaine derivative of tetrapentylcalix[4]resorcine (C5-CB) as a capping agent for AgNPs. It is found that the syntheses of the AgNPs resulted in the formation of the nanocolloids (NCs) containing silver nanoparticles, stabilized by the C5-CB, and the complexes of the silver ions and the C5-CB. The NCs are characterized by the absorption spectroscopy, DLS, XRPD, TEM, IR, and TGA/DSC methods. It is shown that an Ag+/C5-CB molar ratio affects the size of the NCs and the AgNPs, their stability, antimicrobial activity, and cytotoxicity. The NCs exhibit bacteriostatic activity against strains of Staphylococcus aureus with multiple drug resistance (MRSA-1 and MRSA-2) as well as a bactericidal activity (against Sa, Ef, and Ec) and a fungicidal activity (against Ca).

Graphical Abstract