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<p>Glioblastoma (GBM) originates from cancerous cells of the central nervous system (CNS) in the brain and spinal cord, and is the most common malignant primary tumor in brain tumors, with a high degree of aggressiveness and resistance to treatment, accounting for 48.6% of CNS malignant tumors. Although metal–organic frameworks (MOFs) have been widely used in drug delivery, developing nanocarriers with both high stability and biocompatibility remains a significant challenge. This study developed a novel composite nano drug delivery system, PLGA-PDI@CP1@1, which combines poly(lactic-co-glycolic acid) (PLGA) and perylene diimide (PDI) with excellent fluorescence properties to effectively encapsulate MOF-based CP1. The system was further loaded with an active compound extracted from ginseng (compound 1) for the treatment of gliomas. Through in vitro cellular experiments, we found that PLGA-PDI@CP1@1 was able to inhibit the proliferation of cancer cells by suppressing the expression of the glioma proliferation-associated gene MAGED4.</p>

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Characterization and in vitro cellular activity assessment of photodynamic composite nanocarriers for gliomas treatment

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • Yongxu Yang,
  • Wenxiu Li,
  • Junhong Zhou,
  • Yang Yu,
  • Shujie Liu,
  • Qing Xu

摘要

Glioblastoma (GBM) originates from cancerous cells of the central nervous system (CNS) in the brain and spinal cord, and is the most common malignant primary tumor in brain tumors, with a high degree of aggressiveness and resistance to treatment, accounting for 48.6% of CNS malignant tumors. Although metal–organic frameworks (MOFs) have been widely used in drug delivery, developing nanocarriers with both high stability and biocompatibility remains a significant challenge. This study developed a novel composite nano drug delivery system, PLGA-PDI@CP1@1, which combines poly(lactic-co-glycolic acid) (PLGA) and perylene diimide (PDI) with excellent fluorescence properties to effectively encapsulate MOF-based CP1. The system was further loaded with an active compound extracted from ginseng (compound 1) for the treatment of gliomas. Through in vitro cellular experiments, we found that PLGA-PDI@CP1@1 was able to inhibit the proliferation of cancer cells by suppressing the expression of the glioma proliferation-associated gene MAGED4.